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Organic Synthesis, by Michael B. Smith
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Written for a graduate or possibly senior level first organic course in synthesis/reactions for students in chemistry, medicinal chemistry, or pharmacy, "Organic Synthesis" provides in one text a review of basic techniques and tools of organic chemistry as well as a thorough introduction to the synthesis process. The focus of the book is on familiarizing the student with the reactions necessary for synthesis, identifying and developing the strategies and methods of doing synthesis as well as developing the mental processes which must be used in planning and executing a synthesis, and then doing the synthesis. The text includes a unique chapter containing total synthesis done by students along with instructor commentaries as examples of approaches and potential pitfalls to synthesis. Written so that chapters may be used independently for maximum flexibility, the text has two major parts: chapters 2-7 cover functional and protecting groups and chapters 8-9, 11-13 cover carbon bonds. Chapter 1 introduces three fundamental themes found in modern synthetic organic chemistry that are used throughout the text: disconnection, stereochemistry and conformation control. Chapters 2-5 provide a review of the basic principles and tools of organic chemistry with a focus on those reaction types necessary for synthesis, while chapter 6 describes stereochemistry and conformation as applied to organic synthesis. Chapter 10 provides a novel approach to teaching synthesis. Coming after the student has had some introduction to synthesis processes and developed some tools (Chapters 8-9), it provides the student with an overview of the various strategies and ways of doing syntheses, rather than have the student simply read or work through a list of synthesis after synthesis. Chapter 14 contains several total syntheses done by students, along with instructor commentary, as examples of approaches and potential pitfalls. Approximately 40 class-tested and evaluated homework problems accompany each chapter, many with references in the literature to actual experiments.
- Sales Rank: #210812 in Books
- Published on: 1994-01-01
- Original language: English
- Number of items: 1
- Dimensions: 2.54" h x 7.69" w x 9.57" l,
- Binding: Hardcover
- 1250 pages
Most helpful customer reviews
0 of 0 people found the following review helpful.
new ed in 2001
By Howard Mcpherson
If you buy the 1994 edition be sure to download from the author the hundreds of corrections. There are still many more that he does not list. In spite of this I find it is a very useful book, particularly the portions dealing with organoboranes, oxidation and reductions.
5 of 5 people found the following review helpful.
This book is second only to March
By Leib Gershon Mitchell
It's amazing to me that Smith is able to gather so many resources and consolidate them into one place. Everything is there. Reagents. Cross references to books that deal only in reagents, and so on and so on.
Often, one sees textbooks that give reactions and simply assume that they will work without citing a reference where someone has actually gone through the trouble to see if the reaction really will work. (This, I have found, is the quickest way to waste time in the lab. The easier it is to locate a protocol, the higher your lab productivity is.)
It's also good to see that he's taken the time and trouble to whittle away some of the pretty colors that a lot of books put in in order to try to draw the reader's attention away from the glaring lack of substance.
This book may, in the next few years, supercede the March text because a good number of his references are from within the past 5 years (50%, I believe), and it is such that if you are working in the lab and need to find *that* particular reference, then you can easily go and look it up.
2 of 2 people found the following review helpful.
An excellent advanced text.
By Thomas F. Wall
The 2/e is a comprehensive look at modern methods in organic synthesis.
Smith avoids the trend, common in many books, of using too many colors and myriad worthless illustrations. He instead provides a clean, easy to read volume for the advanced undergraduate or graduate organic student.
The references at the end of each chapter are outstanding. There are often in excess of 75 citations per chapter, readily allowing further study.
I would like to respond to the criticism of some reviewers regarding typographical errors. The 2/e does seem to be much better than the 1/e in this regard. Also the author maintains a well documented list of typos on his website.
All in all, this book is easily the rival of Carey & Sundberg's Part B and well worth the investment for any organic/pharm chemists out there.
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